Perfil de susceptibilidade aos antimicrobianos de Mycobacterium tuberculosis complex isolados em adultos atendidos no Hospital Distrital da Manhiça entre Janeiro de 2022 e Junho de 2023

Abstract

The prevalence of tuberculosis in Mozambique is 361 cases/100,000 inhabitants with a mortality rate of 31%, constituting a public health problem. In the southern part of the country, the district of Manhiça has high levels of seropositivity in adults (39.9%) and tuberculosis is an endemic disease that causes the most deaths in children and adults (847/100,000 living with HIV). The transmission and generation of strains resistant to antibiotics used in the treatment of tuberculosis increase the challenges in combating tuberculosis. However, there are few studies on the profile of resistance to anti-tuberculosis drugs, which makes it difficult to guide treatment and makes the success rate in treating tuberculosis low. The present study aimed to evaluate the antimicrobial susceptibility profile of Mycobacterium tuberculosis complex isolated from adults treated at the Manhiça District Hospital between January 2022 and June 2023. The study was carried out including 120 isolates submitted to antibiogram using the MTBDR-plus in-line probe assay method following institutional processing protocols. Out of a total of 120 isolates, 11% showed resistance to at least one antibiotic, of which 10 isolates (8%) were resistant to isoniazid, 5 isolates (4%) were resistant to rifampicin and 2 isolates (2%) were MDR-TB. The results highlight the need for adequate use of first-line antibiotics for the treatment of tuberculosis and resistance testing for Mycobacterium tuberculosis complex. Further phenotypic and molecular studies are needed to estimate the frequency of resistance of M. tuberculosis complex strains circulating in the country(TRADUÇÃO NOSSA)