Síntese de compostos biologicamente activos na base de sulfonamidas

Abstract

Organic compounds that have biological activity and are potentially antifungal have been synthesized. Such compounds, called N-Acetyl arenesulfonamides, have the following general formula: where: R = H, CH3, Cl, HOOC; R' = CH3, CH2Cl, CC13, CN; The compounds were synthesized from sulfonamides, through acetylation reactions of sulfonamide nitrogen. The acetylation was carried out by esters (ethylcyanoacetic ester), anhydrides and chlorides of the acids: acetic, monochloroacetic and trichloroacetic. A total of nine potential antifungal compounds were synthesized, whose structures and chemical composition were confirmed by Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectra and by analysis of elemental nitrogen and neutralization equivalent respectively. Preliminary tests of antifungal activity were carried out and the results were satisfactory. It is intended that these compounds are incorporated into animal feed in order to inhibit the growth of fungi and consequently mycotoxins. The Faculty of Agronomy is studying the possibility of the same compounds being used as nematicides.