Síntese de derivados do ácido anacárdico

Abstract

Right after the first years of the existence of UEM, at the then Center for University Studies of Mozambique, the area of ​​scientific research deserved some attention, but little was done in relation to Cashew Nut Shell Liquid (CNSL), an extremely important extractable resource of the chestnut shell. of which Mozambique could once be the largest producer in the world. In this perspective and in an attempt to reverse this situation, a group of researchers from the Department of Chemistry have been concerned with studying the CNSL and its derivatives with a view to making full use of this raw material, known for its immense biological activity. Due to the phenolic characteristic and the long alkyl and unsaturated chain, the constituents of CNSL, in particular anacardic acid, have great biological activity as a molluscicide, antitumor, antibacterial, carcinogen and are part of raw material for various industries such as pharmaceuticals, cosmetics, veneers, insecticides, among others. It is known that the biological activity of alkylsalicylic acids depends on the side chain, so it is intended with the present work to prepare alkoxysalicylic acids in order to study the influence of this type of chain on the biological activity. The synthesis of 6-dodecyloxy-2-hydroxybenzoic acid was made from 2-6-dihydroxybenzoic acid in three main steps, namely: Esterification, alkylation and hydrolysis. The esterification of 2,6-dihydroxybenzoic acid was carried out with ethanol in an acidic medium while the alkylation and hydrolysis were carried out with 1-bromododecane in a basic medium and sodium hydroxide, respectively. All reactions were monitored by thin layer chromatography and the purified products were characterized with the aid of nuclear magnetic resonance, infrared, gas chromatography and mass spectrometry (TRADUÇÃO NOSSA)