Furtural como composto de partida na síntese de substância bio-activas potenciais tuberculostácticos e anti-sépticos

Abstract

The present work is an attempt to synthesize biologically active compounds, with tuberculostatic and antiseptic potential, using furfural as starting material. A bibliographical research was carried out on tuberculosis, a communicable disease considered one of the main causes of death from infectious diseases in the world. In Mozambique, the total number of reported TB cases increases from year to year. The data obtained allow us to assume that the increase in the number of cases is related to a greater capacity to alert the growing number of TB cases associated with HIV. Drug resistance is one of the constraints in the treatment and control of the transmission of tuberculosis, thus constituting a great challenge for society, seeking new combat agents in order to mitigate the effects of this disease. For this purpose furfural can be used as a raw material. The second part of the bibliographical research is directed to furfural, taking into account the physicochemical properties and the methods of obtaining it, both laboratory and industrial. The proposals are: • the simple modified furfural synthesis technique under laboratory conditions in the chemistry department; • the method for obtaining Isonicotinoylhydrazon furfuralacetone, which can be used for the synthesis of new tuberculostatic agents. In this work, the antiseptic 5-nitro-2-furfuraldehyde semicarbazone was also synthesized with the chemical purpose of transforming it, in order to continue researching new biologically active compounds. The interesting reaction between Formaldehyde and Isoniazid with formation of Bis-isonicotinoylhydrazinomethane was also carried out. The purity of synthesized and isolated compounds was confirmed by melting points, IR, NMR and Mass spectroscopy and was monitored by TLC. (TRADUÇÃO NOSSA)